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KMID : 0368820050440020165
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Journal of the Korean Neuropsychiatr Association
2005 Volume.44 No. 2 p.165 ~ p.175
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Efficacy and Tolerability of Mirtazapine and Sertraline in Treatment of Patients with Posttraumatic Stress Disorder with Depression: A Randomized Open Label Trial.
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Chung Moon-Yong
Min Kyung-Ho
Jun Yong-Ju
Kim Sung-Soo
Kim Wan-Chul
Jun Eun-Mi
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Abstract
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Objectives: The aim of this study was to investigate the potential use of mirtazapine in Korean veterans diagnosed with PTSD, by comparing it with sertraline, a drug approved for use in PTSD in the USA.
Methods: Efficacy was eveluated by Clinician Adninistered PTSD Scale (CAPS-2), the Hamilton Rating Scale for Depressin (HAMD-17) and the Clinical Global lmpresaion Scale (CGI), at baseline and week 1, 2, 6. Response was defined as a > or =30% decrease in CAPS-2 total score, a > or =50% decrease in total HAMD-17 score, and s CGI-I score<3.
Results: 51 patients on mirtazapine (measn age/duration of illness:59.1/33.5 yrs) and 49 on sertratine (mean age/duration of illness:60.6/35.6 years) completed the study. Mean daily dosage was 34.1 mg for mirtazapine and 101.5 mg for sertraline. On CAPS-2 total score more patients responded in the mirtazapine group at weak 1 (13 vs. 2%) and week 2 (51vs. 31%). At week 6 this difference was statistically significant (88 vs. 69%, p=0.039), CAPS-2 total score. HAMD-17 total score and CGI-I score decreased significantly in both groups, with no significant differences between groups on all time points. Main side effects for the rnirtazapine group:dry mouth (19.8%) and constipation (19.6%), somnolence (15.7%), weight gain (1.96%). For the sertraline group:indigestion (14.3%), palpitation (6.1%) agitation (2.0%), epigastric soreness (2.0%), insomnia (2.0%), sexual dysfunction (2.0%).
Conclusion: Mirtazapine appeared to be an effective and well-tolerated treatment for PTSD in Korean veterans.
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KEYWORD
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PTSD, Mirtazapine, Sertraline, Korea
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